Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes
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چکیده
منابع مشابه
The aldose reductase controversy.
ext to the debate as to whether chronic hyperglycemia is the primary cause of the late vascular complications of diabetes, the longest running controversy among researchers and clinicians studying this disease is the role of the sorbitol pathway, particularly its initial enzymatic step, the reduction of glucose to sorbitol by aldose reductase in the pathogenesis of these complications. Because ...
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amblyopia: a comprehensive survey of outcome. Eye 1992; 6: 300-4. 7 Lithander J, Sjorstrand J. Anisometropic and strabismic amblyopia in the age group 2 years and above: a prospective study of the results of treatment. retinoscopy by used to screen infants for amblyopia? A longitudinal study of refraction in the first year of life. Polymegathism is a term used to describe increased variability ...
متن کاملAldose Reductase in The Retina
Aldose reductase (E.C. 1.1.1.21), an intracellular enzyme of polyol pathway, catalyzes NADPHdependent reduction of glucose to sorbitol. Under normoglycemia, most of the cellular glucose is phosphorylated into glucose-6-phosphate by hexokinase. A minor part of non-phosphorylated glucose enters the polyol pathway, the alternate route of glucose metabolism. However, under hyperglycemia, because of...
متن کاملActivators and inhibitors of lens aldose reductase.
Aldose reductase in a highly purified state is unstable. It requires the presence of thiol groups to maintain it in an active form. The enzyme apparently exists in 3 forms, only one of which is active. Tetramethylene glutaric acid (TMG) is an effective aldose reductase inhibitor. However, a relatively high level of TMG is needed to depress dulcitol synthesis in the lens incubated in a galactose...
متن کاملIsolation and Properties of Lens Aldose Reductase.
Exposure of the lens of the eye to a high concentration of an aldose, such as n-glucose, n-galactose, or n-xylose, results in the accumulation of the corresponding sugar alcohols. The high concentration which t.hese alcohols reach within the lens fibers appears to be responsible for t,he loss of clarity of the lens that is observed in experimental sugar cataracts (1). The reduced triphosphopyri...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2001
ISSN: 0014-2956
DOI: 10.1046/j.1432-1327.1999.00110.x